Can I read Co‐delivery of anti‐vascular endothelial growth factor siRNA and doxorubicin by multifunctional polymeric micelle for tumor growth suppression on EtoBox?

Co‐delivery of anti‐vascular endothelial growth factor siRNA and doxorubicin by multifunctional polymeric micelle for tumor growth suppression by Hong‐Yi Huang; Wei‐Ti Kuo; Ming‐Ju Chou; Yi‐You Huang is a Engineering article available to read on EtoBox.

What is Co‐delivery of anti‐vascular endothelial growth factor siRNA and doxorubicin by multifunctional polymeric micelle for tumor growth suppression about?

## Abstract Nonviral gene carriers composed of biodegradable polymers or lipids have been considered as a safer alternative for gene carriers over viral vectors. We have developed multifunctional nanomicelles for both drug and gene delivery application. Polyethylenimine (PEI) was modified by grafting stearic acid (SA) and further formulated to polymeric micelles (PEI‐SA) with positive surface charge for gene delivery evaluation. Our results showed that PEI‐SA micelles provided high siRNA binding efficiency and exhibited low cytotoxicity compared with unmodified PEI. siRNA delivered by PEI‐SA carriers also demonstrated significantly higher cellular uptake efficiency and stability even in the presence of serum proteins when compared with free siRNA. The post‐transcriptional gene silencing efficiency was greatly improved by the polyplex formulated by 10k PEI‐SA/siRNA. In the animal intratumoral model study, the combination of co‐delivering doxorubicin and vascular endothelial growth factor (VEGF) siRNA delivered by PEI‐SA micelles showed a promising effect on anti‐tumor growth. The amphiphilic structure of PEI‐SA micelles provides advantages for multifunctional tasks; such that hydrop

Who reads Co‐delivery of anti‐vascular endothelial growth factor siRNA and doxorubicin by multifunctional polymeric micelle for tumor growth suppression?

Author

Hong‐Yi Huang; Wei‐Ti Kuo; Ming‐Ju Chou; Yi‐You Huang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)