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Can I read Development of a Clinical Assay to Measure Chlorinated Tyrosine in Hair and Tissue Samples Using a Mouse Chlorine Inhalation Exposure Model on EtoBox?
Development of a Clinical Assay to Measure Chlorinated Tyrosine in Hair and Tissue Samples Using a Mouse Chlorine Inhalation Exposure Model by Brooke G. Pantazides; Brian S. Crow; Jennifer Quiñones-González; Jonas W. Perez; Jill A. Harvilchuck; Jeffrey J. Wallery; Tom C. Hu; Jerry D. Thomas; Rudolph C. Johnson; Thomas A. Blake is a Chemistry article available to read on EtoBox.
What is Development of a Clinical Assay to Measure Chlorinated Tyrosine in Hair and Tissue Samples Using a Mouse Chlorine Inhalation Exposure Model about?
Chlorine is a toxic industrial chemical with a history of use as a chemical weapon. Chlorine is also produced, stored, and transported in bulk making it a high-priority pulmonary threat in the USA. Due to the high reactivity of chlorine, few biomarkers exist to identify exposure in clinical and environmental samples. Our laboratory evaluates acute chlorine exposure in clinical samples by measuring 3-chlorotyrosine (Cl-Tyr) and 3,5-dichlorotyrosine (Cl 2 -Tyr) using liquid chromatography tandem mass spectrometry (LC-MS/MS). Individuals can have elevated biomarker levels due to their environment and chronic health conditions, but levels are significantly lower in individuals exposed to chlorine. Historically these biomarkers have been evaluated in serum, plasma, blood, and bronchoalveolar lavage (BAL) fluid. We report the expansion into hair and lung tissue samples using our newly developed tissue homogenization protocol which fits seamlessly with our current chlorinated tyrosine quantitative assay. Furthermore, we have updated the chlorinated tyrosine assay to improve throughput and ruggedness and reduce sample volume requirements. The improved assay was used to measure chlorinated
Who reads Development of a Clinical Assay to Measure Chlorinated Tyrosine in Hair and Tissue Samples Using a Mouse Chlorine Inhalation Exposure Model?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Brooke G. Pantazides; Brian S. Crow; Jennifer Quiñones-González; Jonas W. Perez; Jill A. Harvilchuck; Jeffrey J. Wallery; Tom C. Hu; Jerry D. Thomas; Rudolph C. Johnson; Thomas A. Blake
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)