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Targeting Immune Dysfunction in Aging by Simone Borgoni; Ksenia S. Kudryashova; Ksenia Burka; João Pedro de Magalhães is a Medicine article available to read on EtoBox.

What is Targeting Immune Dysfunction in Aging about?

Human aging is a multifactorial phenomenon that affects numerous organ systems and cellular processes, with the immune system being one of the most dysregulated. Immunosenescence, the gradual deterioration of the immune system, and inflammaging, a chronic inflammatory state that persists in the elderly, are among the plethora of immune changes that occur during aging. Almost all populations of immune cells change with age in terms of numbers and/or activity. These alterations are in general highly detrimental, resulting in an increased susceptibility to infections, reduced healing abilities, and altered homeostasis that promote the emergence of age-associated diseases such as cancer, diabetes, and other diseases associated with inflammation. Thanks to recent developments, several strategies have been proposed to target central immunological processes or specific immune subpopulations affected by aging. These therapeutic approaches could soon be applied in the clinic to slow down or even reverse specific age-induced immune changes in order to rejuvenate the immune system and prevent or reduce the impact of various diseases. Due to its systemic nature and interconnection with all the

Who reads Targeting Immune Dysfunction in Aging?

Author

Simone Borgoni; Ksenia S. Kudryashova; Ksenia Burka; João Pedro de Magalhães

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)