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Systematic Review of Subsequent Pregnancy Outcomes in Couples with Parental Abnormal Chromosomal Karyotypes and Recurrent Pregnancy Loss by Shan Li; Peng-Sheng Zheng; Hong Mei Ma; Qian Feng; Yan Ru Zhang; Qin Shu Li; Jing Jing He; Wen Fang Liu is a Medicine article available to read on EtoBox.
What is Systematic Review of Subsequent Pregnancy Outcomes in Couples with Parental Abnormal Chromosomal Karyotypes and Recurrent Pregnancy Loss about?
## Objective: To evaluate the current evidence of pregnancy outcomes among couples with recurrent pregnancy loss (rpl) with abnormal karyotypes vs. those with normal karyotypes and among couples with rpl and abnormal karyotypes after receiving expectant management vs. preimplantation genetic diagnosis (pgd). ## Design: Systematic review and meta-analysis. ## Setting: Academic medical centers. ## Patient(s): Pregnancy outcomes in 6,301 couples with rpl who conceived without medical intervention in 11 studies were analyzed. however, only 2 studies addressed the outcomes of couples with rpl and abnormal karyotypes after expectant management (75 cases) vs. pgd (50 cases). ## Intervention(s): None. ## Main outcome measure(s): The pregnancy outcomes in couples with rpl with abnormal and normal karyotypes across included studies were evaluated. ## Result(s): Compared with those with a normal karyotype, a significantly lower first pregnancy live birth rate (lbr) was found in couples with rpl with abnormal karyotypes (58.5% vs. 71.9%; odds ratio [or], 0.55; 95% confidence interval [ci], 0.46-0.65; i =27%). a markedly decreased first pregnancy lbr was found in couples with a translocation (5
Who reads Systematic Review of Subsequent Pregnancy Outcomes in Couples with Parental Abnormal Chromosomal Karyotypes and Recurrent Pregnancy Loss?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shan Li; Peng-Sheng Zheng; Hong Mei Ma; Qian Feng; Yan Ru Zhang; Qin Shu Li; Jing Jing He; Wen Fang Liu
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)