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Can I read Patient‐specific Voxel‐level Dose Prescription for Prostate Cancer Radiotherapy Considering Tumor Cell Density and Grade Distribution on EtoBox?
Patient‐specific Voxel‐level Dose Prescription for Prostate Cancer Radiotherapy Considering Tumor Cell Density and Grade Distribution by Yutong Zhao; Annette Haworth; Hayley M. Reynolds; Emily J. Her; Yu Sun; Robert Finnegan; Pejman Rowshanfarzad; Martin A. Ebert is a Medicine article available to read on EtoBox.
What is Patient‐specific Voxel‐level Dose Prescription for Prostate Cancer Radiotherapy Considering Tumor Cell Density and Grade Distribution about?
Background: In prostate radiation therapy, recent studies have indicated a benefit in increasing the dose to intraprostatic lesions (IPL) compared with standard whole gland radiation therapy. Such approaches typically aim to deliver a target dose to the IPL(s) with no deliberate effort to modulate the dose within the IPL. Prostate cancers demonstrate intra-tumor heterogeneity and hence it is hypothesized that further gains in the optimal delivery of radiation therapy can be achieved through modulation of the dose distribution within the tumor. To account for tumor heterogeneity, biologically targeted radiation therapy (BiRT) aims to utilize a voxel-wise approach to IPL dose prescription by incorporating knowledge of the spatial distribution of tumor characteristics. Purpose: The aim of this study was to develop a workflow for generating voxelwise optimal dose prescriptions that maximize patient tumor control probability (TCP), and evaluate the feasibility and benefits of applying this workflow on a cohort of 62 prostate cancer patients. Method: The source data for this proof -of -concept study included high resolution histology images annotated with tumor location and grade. Image
Who reads Patient‐specific Voxel‐level Dose Prescription for Prostate Cancer Radiotherapy Considering Tumor Cell Density and Grade Distribution?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yutong Zhao; Annette Haworth; Hayley M. Reynolds; Emily J. Her; Yu Sun; Robert Finnegan; Pejman Rowshanfarzad; Martin A. Ebert
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)