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Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism by Philip Grant; Pushkar Sharma; Harish C. Pant is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism about?

Cyclin‐dependent kinase 5 (Cdk5), a complex of Cdk5 and its activator p35 (Cdk5/p35), phosphorylates diverse substrates which have multifunctional roles in the nervous system. During development, it participates in neuronal differentiation, migration, axon outgrowth and synaptogenesis. Cdk5, acting together with other kinases, phosphorylates numerous KSPXK consensus motifs in diverse cytoskeletal protein target molecules, including neurofilaments, and microtubule associated proteins, tau and MAPs. Phosphorylation regulates the dynamic interactions of cytoskeletal proteins with one another during all aspects of neurogenesis and axon radial growth. In this review we shall focus on Cdk5 and its regulation as it modulates neurofilament metabolism in axon outgrowth, cytoskeletal stabilization and radial growth. We suggest that Cdk5/p35 forms compartmentalized macromolecular complexes of cytoskeletal substrates, other neuronal kinases, phosphatases and activators (‘phosphorylation machines’) which facilitate the dynamic molecular interactions that underlie these processes.

Who reads Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism?

Author

Philip Grant; Pushkar Sharma; Harish C. Pant

Publisher

John Wiley and Sons; Springer; Wiley (Blackwell Publishing); Springer-Verlag; Blackwell Publishing Inc.; Springer Verlag; Wiley; Springer Science and Business Media LLC (ISSN 1432-1327)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Physical Sciences)