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Patient Defined Dichotomous End Points for Remission and Clinical Improvement in Ulcerative Colitis by P D R Higgins is a Medicine article available to read on EtoBox.

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## Background and aims: Ulcerative colitis disease activity indices offer good statistical power but small changes in these indices may not be clinically important. there are no validated definitions of remission or of significant improvement for these indices. the use of clinically important end points would strengthen the validity of study outcomes. our aims were to identify objective end points in standard disease activity indices for remission and for improvement in ulcerative colitis. ## Methods: Sixty six consecutive patients with ulcerative colitis provided information about remission status and their disease activity. at a return visit 1-14 months later, these patients provided information about the change in their disease activity, and non-invasive indices were measured. ## Results: Specific objective end points for determining remission with four standard indices and a quality of life instrument were determined (st mark's <3.5, ulcerative colitis disease activity index <2.5, simple clinical colitis activity index (sccai) <2.5, seo 205). these cut offs also identified patients who met a regulatory definition of remission. specific objective end points for clinical improve

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Author

P D R Higgins

Publisher

BMJ

Published

2005

Language

EN

Field

Medicine (Health Sciences)