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CRISPR Base Editing of HBV S Gene by DIVYA ls is a document available to read on EtoBox.
What is CRISPR Base Editing of HBV S Gene about?
1) Researchers designed a single guide RNA (sgRNA) to introduce a premature stop codon in the hepatitis B virus (HBV) S gene using CRISPR cytidine base editing (CBE). 2) CBE mediated editing of the S gene in infected cells, reducing HBsAg secretion by 92% and intracellular HBsAg by 84%. 3) No off-target editing was detected in potential off-target sites in the host genome, demonstrating CBE
- Author
- DIVYA ls
- Language
- EN