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Fluorouracil/methotrexate Bilateral Morgagnian cataract: case report A 65-year-old woman developed bilateral Morgagnian cataract following treatment with fluorouracil and methotrexate for oral cavity squamous cell carcinoma.The woman, who had stage T4bN1M0 oral cavity squamous cell carcinoma, presented to our outpatient department (OPD) with complaints of gradual diminution of vision in both eyes for the past 6 months. She had been a chronic tobacco and betel nut chewer. Her reports revealed that she had undergone right segmental mandibulectomy with modified radical neck dissection type II. The malignancy had led to lower alveolus bone destruction and an enlarged lymph node in level 1b. Subsequently, she was treated with neoadjuvant chemotherapy (NACT) with IV fluorouracil [5-fluorouracil] 500mg and IV methotrexate 50mg weekly for three cycles prior to surgery. Her previous ocular record (6 months prior) revealed a best corrected visual acuity (BCVA) of 6/6, grade 1 nuclear sclerotic cataract, and normal fundus in both the eye. She checked with a local ophthalmologist who diagnosed her with bilateral Morgagnian cataracts and referred her to the center for subsequent management. Sne

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Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)