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The RNA component of telomerase as a marker of biologic potential and clinical outcome in childhood neuroblastic tumors by Anirban Maitra; Kazuo Yashima; Asha Rathi; Charles F. Timmons; Beverly Barton Rogers; Jerry W. Shay; Adi F. Gazdar is a Medicine article available to read on EtoBox.

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## Background: Telomerase is a ribonucleoprotein enzyme associated with cellular immortality that may be useful in determining the biologic potential of a tumor. neuroblastoma (nb), ganglioneuroblastoma (gnb), and ganglioneuroma (gn) are neuroblastic tumors (nts) that exhibit a spectrum of histologic features and are often associated with unpredictable behavior and clinical outcome. ## Methods: The authors investigated the expression of the rna component of human telomerase (htr) by in situ hybridization in 32 cases of nts (including 24 nbs, 4 gnbs, and 4 gns), using [35s]-utp labeled single stranded sense and antisense rna probes. eight nbs were early stage, 12 nbs were advanced stage, and 4 nbs were stage ivs, a widely metastatic variant associated with an excellent clinical prognosis. four nbs had n-myc amplification. in addition, the authors compared a proliferation marker, mib-1, with htr expression in a subset of tumors. ## Results: Thirty of 32 nts expressed htr, with expression varying from weak (1+) to intense (4+). most advanced stage nbs (9 of 12) and only 2 of 8 early stage nbs had moderate to intense (2 to 4-) expression of htr. the remaining early stage tumors (6 of 8

Who reads The RNA component of telomerase as a marker of biologic potential and clinical outcome in childhood neuroblastic tumors?

Author

Anirban Maitra; Kazuo Yashima; Asha Rathi; Charles F. Timmons; Beverly Barton Rogers; Jerry W. Shay; Adi F. Gazdar

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1999

Language

EN

Field

Medicine (Health Sciences)