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Can I read Phenotypic, Biochemical, and Genetic Analysis of KPC-41, a KPC-3 Variant Conferring Resistance to Ceftazidime-Avibactam and Exhibiting Reduced Carbapenemase Activity on EtoBox?
Phenotypic, Biochemical, and Genetic Analysis of KPC-41, a KPC-3 Variant Conferring Resistance to Ceftazidime-Avibactam and Exhibiting Reduced Carbapenemase Activity by Linda Mueller; Amandine Masseron; Guy Prod’Hom; Tatiana Galperine; Gilbert Greub; Laurent Poirel; Patrice Nordmann is a Medicine article available to read on EtoBox.
What is Phenotypic, Biochemical, and Genetic Analysis of KPC-41, a KPC-3 Variant Conferring Resistance to Ceftazidime-Avibactam and Exhibiting Reduced Carbapenemase Activity about?
A novel KPC variant, KPC-41, was identified in a clinical isolate from Switzerland. This ß-lactamase possessed a three amino-acid insertion (Pro-Asn-Lys) located between amino acids 269 and 270 compared to the KPC-3 amino acid sequence. Cloning and expression of the gene in , followed by determination of MIC values and kinetic parameters, showed that KPC-41, compared to KPC-3, has an increased affinity to ceftazidime and a decreased sensitivity to avibactam, leading to resistance to ceftazidime-avibactam once produced in Furthermore, KPC-41 exhibited a drastic decrease of its carbapenemase activity. This report highlights that a diversity of KPC variants conferring resistance to ceftazidime-avibactam already circulate in Europe.
Who reads Phenotypic, Biochemical, and Genetic Analysis of KPC-41, a KPC-3 Variant Conferring Resistance to Ceftazidime-Avibactam and Exhibiting Reduced Carbapenemase Activity?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Linda Mueller; Amandine Masseron; Guy Prod’Hom; Tatiana Galperine; Gilbert Greub; Laurent Poirel; Patrice Nordmann
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)