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Myrtenol Inhibits Biofilm Formation and Virulence in the Drug-Resistant Acinetobacter baumannii : Insights into the Molecular Mechanisms by Lei Liu; Bin Liu; Liang Li; Ming-Xin He; Xiang-Dong Zhou; Qi Li is a Medicine article available to read on EtoBox.
What is Myrtenol Inhibits Biofilm Formation and Virulence in the Drug-Resistant Acinetobacter baumannii : Insights into the Molecular Mechanisms about?
## Background __blaNDM-1__-producing __Acinetobacter baumannii__ (BP-AB) remains a critical problem in nosocomial infections, because of its resistance mediated by the biofilm formation and virulence factors. No studies have confirmed myrtenol’s efficacy in inhibiting the biofilm formation and virulence associated with biofilm of BP-AB. ## Methods The tested concentrations of myrtenol were wild type (A), 50 μg/mL (B), 100 μg/mL (C), 200 μg/mL (D), 250 μg/mL (E), and 300 μg/mL (F). ## Results The BP-AB biofilm inhibition was significantly higher in the D, E, and F groups than in the A, B, and C groups. Myrtenol significantly reduced the air-liquid interface ring formation in glass tubes. It also effectively inhibited the attachment of BP-AB strains on polystyrene surfaces as shown by crystal violet staining. Microscopy showed a significant reduction in biofilm formation with dispersed BP-AB strains. The confocal laser scanning microscopy analysis showed a significant reduction in the biofilm’s biomass, covered surface area, and thickness. The scanning electron microscopy analysis revealed significantly fewer BP-AB aggregates on the coverslip surface. In the CompStat analysis, the bi
Who reads Myrtenol Inhibits Biofilm Formation and Virulence in the Drug-Resistant Acinetobacter baumannii : Insights into the Molecular Mechanisms?
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- Author
- Lei Liu; Bin Liu; Liang Li; Ming-Xin He; Xiang-Dong Zhou; Qi Li
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)