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Electrothermal equivalent three-dimensional Finite Element Model of a single neuron by Cinelli, Ilaria; Destrade, Michel; Duffy, Maeve; McHugh, Peter is a scholarly article available to read on EtoBox.

What is Electrothermal equivalent three-dimensional Finite Element Model of a single neuron about?

Objective: We propose a novel approach for modelling the inter-dependence of electrical and mechanical phenomena in nervous cells, by using electro-thermal equivalences in finite element (FE) analysis so that existing thermo-mechanical tools can be applied. Methods: First, the equivalence between electrical and thermal properties of the nerve materials is established, and results of a pure heat conduction analysis performed in Abaqus CAE Software 6.13-3 are validated with analytical solutions for a range of steady and transient conditions. This validation includes the definition of equivalent active membrane properties that enable prediction of the action potential. Then, as a step towards fully coupled models, electromechanical coupling is implemented through the definition of equivalent piezoelectric properties of the nerve membrane using the thermal expansion coefficient, enabling prediction of the mechanical response of the nerve to the action potential. Results: Results of the coupled electro-mechanical model are validated with previously published experimental results of deformation for the squid giant axon, crab nerve fibre and garfish olfactory nerve fibre. Conclusion: A si

Author

Cinelli, Ilaria; Destrade, Michel; Duffy, Maeve; McHugh, Peter

Published

2020

Language

EN