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Two-dimensional Condensation of Pyrimidine Oligonucleotides During Their Self-assemblies at Mercury Based Surfaces by Stanislav Hasoň; Vladimír Vetterl; Miroslav Fojta is a Engineering article available to read on EtoBox.

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For the first time it is shown that homopyrimidine oligodeoxynucleotides (ODNs) adsorbed at mercury or amalgam electrode surface can condensate upon applying negative potentials (around -1.35 V vs. Ag/AgCl/3M KCl). This 2D condensation resulted in formation of capacitance pits on the C-E curves resembling those observed earlier with monomeric nucleic acid bases, nucleosides and nucleotides. Differences in behavior of the condensed layers of dT 30 and dC 30 ODNs, reflecting different physico-chemical and electrochemical properties of thymine and cytosine, were observed. Formation of the ODN condensed film involved reorientation of the oligonucleotide molecules firmly adsorbed at the electrode and took place even in the absence of any ODN in the bulk of solution. Homopurine ODNs did not form these twodimensional (2D) condensed monolayers under the same conditions. A preliminary thermodynamic analysis of the condensed ODN layers is presented.

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Author

Stanislav Hasoň; Vladimír Vetterl; Miroslav Fojta

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0013-4686)

Published

2008

Language

EN

Field

Engineering (Physical Sciences)