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Synthesis and Characterization of Polycaprolactone for Anterior Cruciate Ligament Regeneration by Ayse Cansu Gurlek; Burcu Sevinc; Ece Bayrak; Cevat Erisken is a Engineering article available to read on EtoBox.

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Anterior cruciate ligament (ACL) is the most frequently torn ligament in the knee, and complete healing is unlikely due to lack of vascularization. Current approaches for the treatment of ACL injuries include surgical interventions and grafting, however recent reports show that surgeries have 94% recurrency, and that repaired tissues are biomechanically inferior to the native tissue. These necessitate the need for new strategies for scar-free repair/regeneration of ACL injuries. Polycaprolactone (PCL) is a biodegradable and biocompatible synthetic polymer, which has been widely used in the connective tissue repair/regeneration attempts. Here, we report on the synthesis of PCL via ring opening polymerization using ε-caprolactone as the monomer, and ammonium heptamolybdate as a catalyst. The synthesized PCL was characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy. It was then processed using electrospinning to form nanofiber-based scaffolds. These scaffolds were characterized in terms of surface as well as mechanical properties, and compared to the properties of commercially available PCL, and of native ACL tissue harves

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Author

Ayse Cansu Gurlek; Burcu Sevinc; Ece Bayrak; Cevat Erisken

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0928-4931)

Published

2016

Language

EN

Field

Engineering (Physical Sciences)