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Can I read Pharmacological and Non-pharmacological Interventions to Prevent Delirium After Cardiac Surgery: a Protocol for a Systematic Review and Meta-analysis on EtoBox?

Pharmacological and Non-pharmacological Interventions to Prevent Delirium After Cardiac Surgery: a Protocol for a Systematic Review and Meta-analysis by Elizabeth Cottuli de Cothi; Rachel Perry; Rahul Kota; Terrie Walker-Smith; Jonathan David Barnes; Maria Pufulete; Ben Gibbison is a Medicine article available to read on EtoBox.

What is Pharmacological and Non-pharmacological Interventions to Prevent Delirium After Cardiac Surgery: a Protocol for a Systematic Review and Meta-analysis about?

## Introduction Delirium is a syndrome characterised by a disturbance in attention, awareness and cognition as a result of another physical condition. It occurs in up to 50% of patients after cardiac surgery and is associated with increased mortality, prolonged intensive care and hospital stay and long-term cognitive dysfunction. Identifying effective preventive interventions is important. We will therefore conduct a systematic review to identify all randomised controlled studies that have tested a pharmacological or non-pharmacological intervention to prevent delirium. ## Methods and analysis We will search electronic databases (CDSR (Reviews), CENTRAL (Trials), MEDLINE Ovid, Embase Ovid, PsycINFO Ovid) as well as trial registers (clinicaltrials.gov and ISCRTN) for randomised controlled trials of both pharmacological and non-pharmacological interventions designed to prevent delirium after cardiac surgery in adults. Screening of search results and data extraction from included articles will be performed by two independent reviewers using Rayyan. The primary outcome will be the incidence of delirium. Secondary outcomes include: duration of postoperative delirium, all-cause mortality

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It is typically read by researchers, students, and practitioners in Medicine.

Author
Elizabeth Cottuli de Cothi; Rachel Perry; Rahul Kota; Terrie Walker-Smith; Jonathan David Barnes; Maria Pufulete; Ben Gibbison
Publisher
BMJ Publishing Group
Published
2023
Language
EN
Field
Medicine (Health Sciences)

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