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Activation of Metabotropic Glutamate Receptor 4 Regulates Proliferation and Neural Differentiation in Neural Stem/progenitor Cells of the Rat Subventricular Zone and Increases Phosphatase and Tensin Homolog Protein Expression by Zhichao Zhang; Xiaoyan Zheng; Yingfei Liu; Yan Luan; Li Wang; Lingyu Zhao; Jianshui Zhang; Yumei Tian; Haixia Lu; Xinlin Chen; Yong Liu is a Neuroscience article available to read on EtoBox.
What is Activation of Metabotropic Glutamate Receptor 4 Regulates Proliferation and Neural Differentiation in Neural Stem/progenitor Cells of the Rat Subventricular Zone and Increases Phosphatase and Tensin Homolog Protein Expression about?
## Abstract Neural stem/progenitor cells (NSPCs) persist in the mammalian subventricular zone throughout life, where they can be activated in response to physiological and pathophysiological stimuli. A recent study indicates metabotropic glutamate receptor 4 (mGluR4) is involved in regulating NSPCs behaviors. Therefore, defining mGluR4 function in NSPCs is necessary for determining novel strategies to enhance the intrinsic potential for brain regeneration after injuries. In this study, mGluR4 was functionally expressed in SVZ‐derived NSPCs from male Sprague‐Dawley rats, in which the cyclic adenosine monophosphate concentration was reduced after treatment with the mGluR4‐specific agonist VU0155041. Additionally, lateral ventricle injection of VU0155041 significantly decreased 5‐bromo‐2'‐deoxyuridine (BrdU)^+^ and Ki67^+^ cells, while increased Doublecortin (DCX)/BrdU double‐positive cells in SVZ. In cultured NSPCs, mGluR4 activation decreased the ratio of BrdU^+^ cells, G2/M‐phase cells, and inhibited Cyclin D1 expression, whereas it increased neuron‐specific class III β‐tubulin (Tuj1) expression and the number of Tuj1, DCX, and PSA‐NCAM‐positive cells. However, pharmacological bloc
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- Author
- Zhichao Zhang; Xiaoyan Zheng; Yingfei Liu; Yan Luan; Li Wang; Lingyu Zhao; Jianshui Zhang; Yumei Tian; Haixia Lu; Xinlin Chen; Yong Liu
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)