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Development of a Monoclonal Antibody Against Porcine CD163 SRCR5 Domain Which Partially Blocks Infection of PRRSV by Zhang, Yujiao ;Zhang, Kuan ;Zheng, Hao ;Liu, Changlong ;Jiang, Yifeng ;Du, Nannan ;Li, Liwei ;Li, Guoxin ;Yu, Lingxue ;Zhou, Yanjun ;Tong, Wu ;Zhao, Kuan ;Tong, Guangzhi ;Gao, Fei is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Development of a Monoclonal Antibody Against Porcine CD163 SRCR5 Domain Which Partially Blocks Infection of PRRSV about?
Porcine reproductive and respiratory syndrome virus (PRRSV), which seriously endangers the world pig industry, invades host cells through receptor-mediated endocytosis involving clathrin. CD163 is an essential receptor for PRRSV during its infection of cells. The scavenger receptor cysteine-rich 5 (SRCR5) domain of the CD163 molecule is necessary for PRRSV infection, and interacts with glycoproteins GP2a and GP4 of PRRSV, allowing the virus to infect the host cells. In this study, a monoclonal antibody (mAb) against the SRCR5-6 region of porcine CD163 was developed, and the target epitope of the mAb was determined as TWGTVCDSDF, which is directly adjacent to the ligand-binding pocket (LBP) domain (487-495aa) of CD163. Further study indicated that the mAb could partially block PRRSV infection of its target cells, pulmonary alveolar macrophages. The mAb developed in the study may provide a foundation of antiviral therapy for PRRSV.
Who reads Development of a Monoclonal Antibody Against Porcine CD163 SRCR5 Domain Which Partially Blocks Infection of PRRSV?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Zhang, Yujiao ;Zhang, Kuan ;Zheng, Hao ;Liu, Changlong ;Jiang, Yifeng ;Du, Nannan ;Li, Liwei ;Li, Guoxin ;Yu, Lingxue ;Zhou, Yanjun ;Tong, Wu ;Zhao, Kuan ;Tong, Guangzhi ;Gao, Fei
- Publisher
- Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2014- (ISSN 2297-1769)
- Published
- 2020
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)