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Familial temporal lobe epilepsy: A common disorder identified in twins by Dr Samuel F. Berkovic; Anne McIntosh; R. Anne Howell; Anne Mitchell; Leslie J. Sheffield; John L. Hopper is a Medicine article available to read on EtoBox.

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We describe a new syndrome of familial temporal lobe epilepsy in 38 individuals from 13 unrelated white families. The disorder was first identified in 5 concordant monozygotic twin pairs as part of a large-scale twin study of epilepsy. When idiopathic partial epilepsy syndromes were excluded, the 5 pairs accounted for 23% of monozygotic pairs with partial epilepsies, and 38% of monozygotic pairs with partial epilepsy and no known etiology. Seizure onset for twin and nontwin subjects usually occurred during adolescence or early adult life. Seizure types were simple partial seizures with psychic or autonomic symptoms, infrequent complex partial seizures, and rare secondarily generalized seizures. Electroencephalograms revealed sparse focal temporal interictal epileptiform discharges in 22% of subjects. Magnetic resonance images appeared normal. Nine affected family members (24%) had not been diagnosed prior to the study. Pedigree analysis suggested autosomal dominant inheritance with age-dependent penetrance. The estimated segregation ratio was 0.3, indicating an overall penetrance of GO% assuming autosomal dominant inheritance. The mild and often subtle nature of the symptoms in som

Who reads Familial temporal lobe epilepsy: A common disorder identified in twins?

Author

Dr Samuel F. Berkovic; Anne McIntosh; R. Anne Howell; Anne Mitchell; Leslie J. Sheffield; John L. Hopper

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)

Published

1996

Language

EN

Field

Medicine (Health Sciences)