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TGF-β1-THBS2 Circuit in PDAC Progression by 安景钰 is a document available to read on EtoBox.

What is TGF-β1-THBS2 Circuit in PDAC Progression about?

The study investigates the role of the TGF-β1-THBS2 feedback circuit in the progression of pancreatic ductal adenocarcinoma (PDAC) through the activation of the MAPK pathway via integrin αvβ3/CD36. Elevated THBS2 expression in the tumor stroma, primarily from cancer-associated fibroblasts (CAFs), correlates with poor prognosis in PDAC patients. The findings suggest that targeting THBS2 may offer a novel therapeutic strategy to disrupt the communication between pancreatic cancer cells and the stroma.

Author

安景钰

Language

EN