Can I read Melatonin: Roles in influenza, Covid‐19, and other viral infections on EtoBox?
Melatonin: Roles in influenza, Covid‐19, and other viral infections by Anderson, George; Reiter, Russel J. is a Medicine article available to read on EtoBox.
What is Melatonin: Roles in influenza, Covid‐19, and other viral infections about?
There is a growing appreciation that the regulation of the melatonergic pathways, both pineal and systemic, may be an important aspect in how viruses drive the cellular changes that underpin their control of cellular function. We review the melatonergic pathway role in viral infections, emphasizing influenza and covid-19 infections. Viral, or preexistent, suppression of pineal melatonin disinhibits neutrophil attraction, thereby contributing to an initial "cytokine storm", as well as the regulation of other immune cells. Melatonin induces the circadian gene, Bmal1, which disinhibits the pyruvate dehydrogenase complex (PDC), countering viral inhibition of Bmal1/PDC. PDC drives mitochondrial conversion of pyruvate to acetyl-coenzyme A (acetyl-CoA), thereby increasing the tricarboxylic acid cycle, oxidative phosphorylation, and ATP production. Pineal melatonin suppression attenuates this, preventing the circadian "resetting" of mitochondrial metabolism. This is especially relevant in immune cells, where shifting metabolism from glycolytic to oxidative phosphorylation, switches cells from reactive to quiescent phenotypes. Acetyl-CoA is a necessary cosubstrate for arylalkylamine N-acety
Who reads Melatonin: Roles in influenza, Covid‐19, and other viral infections?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Anderson, George; Reiter, Russel J.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1052-9276)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)