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Can I read Bovine Serum Albumin-based and Dual-responsive Targeted Hollow Mesoporous Silica Nanoparticles for Breast Cancer Therapy on EtoBox?
Bovine Serum Albumin-based and Dual-responsive Targeted Hollow Mesoporous Silica Nanoparticles for Breast Cancer Therapy by Yueli Zhang; Zhilan Ye; Ruixuan He; Yuyang Li; Bei Xiong; Mengqi Yi; Yuqi Chen; Jia Liu; Bo Lu is a Materials Science article available to read on EtoBox.
What is Bovine Serum Albumin-based and Dual-responsive Targeted Hollow Mesoporous Silica Nanoparticles for Breast Cancer Therapy about?
Combination therapy is an effective way to alleviate the shortcoming of monotherapy and enhances therapeutic efficacy. Herein, a distinctive hollow mesoporous silica nanoparticle (HMSNs) encapsulated with folic acid-modified bovine serum albumin (BSA-FA), denoted as HBF, was engineered for tumor targeting and dual-responsive release of loaded-therapeutic agents MD (methylene blue (MB) and doxorubicin (DOX)). The BSA molecule as a ‘‘gatekeeper’’ prevents premature drug leakage and actively unloads the cargos through BSA detachment in response to intracellular glutathione (GSH). Folic acid (FA) promotes the specific intracellular delivery of the drug to folate receptor (FR)-expressing cancer cells to improve the efficacy of chemo-photodynamic therapy (PDT). In vitro drug release profiles showed that the drug carrier could achieve pH/redox-responsive drug release from MD@HBF owing to the cleavage of the imine bonds between HMSNs-CHO and BSA-FA and BSA intramolecular disulfide bond. Additionally, a series of biological evaluations, such as cell uptake experiments, toxicity experiments, and in vivo therapeutic assays indicated that MD@HBF possesses the features of accurately targeting F
Who reads Bovine Serum Albumin-based and Dual-responsive Targeted Hollow Mesoporous Silica Nanoparticles for Breast Cancer Therapy?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Yueli Zhang; Zhilan Ye; Ruixuan He; Yuyang Li; Bei Xiong; Mengqi Yi; Yuqi Chen; Jia Liu; Bo Lu
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)