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Synthesis and characterisation of Cu(II), Ni(II), and Zn(II) complexes of furfural derived from aroylhydrazones bearing aliphatic groups and their interactions with DNA by Gokce, Cansu; Gup, Ramazan is a Chemistry article available to read on EtoBox.

What is Synthesis and characterisation of Cu(II), Ni(II), and Zn(II) complexes of furfural derived from aroylhydrazones bearing aliphatic groups and their interactions with DNA about?

## Abstract Two new Schiff base-hydrazones bearing furan ring, (Z)-4-butoxy-N′-(furan-2-ylmethylene)benzohydrazide (IV) and (Z)-N′-(furan-2-ylmethylene)-4-(hexyloxy)benzohydrazide (V), as well as their Cu(II), Ni(II), and Zn(II) complexes have been synthesised and characterised. The DNA-binding and DNA-cleavage activities of both aroylhydrazone ligands and their transition metal complexes were examined using UV-VIS titration and agarose gel electrophoresis in the presence of an oxidative agent (H2O2). The results indicate that the copper complexes bind significantly to calf thymus DNA and effectively cleave pBR322 DNA whereas the nickel and zinc complexes interact slightly with DNA.

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Author

Gokce, Cansu; Gup, Ramazan

Publisher

Versita; Springer-Verlag; Springer International Publishing AG; Bratislava: Institute of Chemistry Slovak Academy of Sciences; Warszawa: Versita; Heidelberg: Springer, 2006-2014.; Bratislava: Institute of Chemistry Slovak Academy of Sciences; Berlin: De Gruyter, 2015-2016.; Bratislava: Institute of Chemistry Slovak Academy of Sciences; Heidelberg: Springer, 2017-; Bratislava: Institute of Chemistry Slovak Academy of Sciences; Warszawa: De Gruyter, 2016-2016; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0366-6352)

Published

2013

Language

EN

Field

Chemistry (Physical Sciences)