Can I read Comparative Acute Effects of Brimonidine 0.2% Versus Dorzolamide 2% Combined with Beta-blockers in Glaucoma on EtoBox?

Comparative Acute Effects of Brimonidine 0.2% Versus Dorzolamide 2% Combined with Beta-blockers in Glaucoma by M. Centofanti; G. Manni; D. Gregori; F. Cocco; D. Lorenzano; M. G. Bucci is a Medicine article available to read on EtoBox.

What is Comparative Acute Effects of Brimonidine 0.2% Versus Dorzolamide 2% Combined with Beta-blockers in Glaucoma about?

## Purpose: To assess the acute intraocular hypotensive efficacy of brimonidine tartrate 0.2% (a highly selective alpha2-adrenergic agonist) compared with dorzolamide 2% (a topical carbonic anhydrase inhibitor) as adjunct therapy to topical beta-blockers in patients with primary open-angle glaucoma. ## Methods: A randomized cross-over masked study was performed. we enrolled one eye of each of 28 patients who were on different beta-blocker therapy. we measured the intraocular pressure (iop) 2 h after the beta-blocker instillation; we then randomly administered one of the two drugs and we compiled an iop diurnal curve. one month later we repeated the same procedures with the second drug. unpaired mann-whitney u-test was used to compare decreases in iop between the two drugs (p<0.05). ## Results: Both brimonidine 0.2% and dorzolamide 2% have good ocular hypotensive efficacy, significantly lowering iop when compared to beta-blocker therapy alone, for the whole diurnal curve. maximum mean percent iop decrease from baseline was 22.0+/-15.7% (4.0+/-2.9 mmhg) for dorzolamide 2% 6 h after instillation and 35.5+/-16.4% (7.0+/-4.1 mmhg) for brimonidine 0.2% 8 h after administration of the dru

Who reads Comparative Acute Effects of Brimonidine 0.2% Versus Dorzolamide 2% Combined with Beta-blockers in Glaucoma?

Author

M. Centofanti; G. Manni; D. Gregori; F. Cocco; D. Lorenzano; M. G. Bucci

Publisher

Springer Science and Business Media LLC

Published

2000

Language

EN

Field

Medicine (Health Sciences)