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Immunohistochemistry Subtyping of Urothelial Carcinoma Is Feasible in the Daily Practice by Francisco Javier Queipo; Gorka Muñiz Unamunzaga; Begoña Fuertes Negro; Sandra Gracia Fuertes; Marina Álvarez Cortés; Elena Carceller Tejedor; Carmen María Bernal Mañas; Arceli Bono Ariño; Gottfrid Sjödahl; Carmen Beorlegui is a Medicine article available to read on EtoBox.
What is Immunohistochemistry Subtyping of Urothelial Carcinoma Is Feasible in the Daily Practice about?
The preferred treatment of choice in muscle-invasive bladder cancer (MIBC) is usually transurethral resection followed by cystectomy, with neoadjuvant chemotherapy being a second option. As the treatment is associated with relevant side effects, a great effort is being made to improve the selection of patients, with molecular subtyping being one of the main strategies. Our aim was to develop an immunohistochemical algorithm for subtyping MIBCs. After a literature review, we have developed a simple algorithm to subtype MIBCs based on their morphology and three common antibodies: GATA3, CK5/6, and p16. We applied it to 113 muscle-invasive carcinomas. The positivity threshold for GATA3 and CK5/6 was 20% with at least moderate intensity, while p16 was 70% with moderate to intense nuclear and cytoplasmic staining. Cases GATA3 + CK5/6 -were considered luminal, while cases GATA3 -CK5/6 + were classified as nonluminal/basal squamous. Luminal p16 + cases were labeled as genomically unstable and luminal p16 -as Uro-like. Cases GATA3 + CK5/6 + with a predominantly basal pattern were labeled luminal, while diffuse cases were labeled nonluminal/basal squamous. All GATA3-CK5/6 -cases were consid
Who reads Immunohistochemistry Subtyping of Urothelial Carcinoma Is Feasible in the Daily Practice?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Francisco Javier Queipo; Gorka Muñiz Unamunzaga; Begoña Fuertes Negro; Sandra Gracia Fuertes; Marina Álvarez Cortés; Elena Carceller Tejedor; Carmen María Bernal Mañas; Arceli Bono Ariño; Gottfrid Sjödahl; Carmen Beorlegui
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)