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Development and Validation of an Ion Chromatography Method for the Determination of Phosphate-binding of Lanthanum Carbonate by Raghu Samy; Patrick J. Faustino; Wallace Adams; Lawrence Yu; Mansoor A. Khan; Yongsheng Yang is a Chemistry article available to read on EtoBox.
What is Development and Validation of an Ion Chromatography Method for the Determination of Phosphate-binding of Lanthanum Carbonate about?
Lanthanum carbonate is indicated to reduce serum phosphate in patients with end stage renal disease (ESRD). When given orally, lanthanum carbonate dissociates in the acid environment of the upper gastrointestinal tract to release lanthanum ions. The free lanthanum ions bind with dietary phosphate released from food during digestion to form highly insoluble lanthanum-phosphate complexes which prevent the absorption of phosphate, consequently reduce the serum phosphate. In order to evaluate the in vitro binding capacity of lanthanum carbonate, a simple and efficient ion chromatography (IC) method was developed and validated for determination of phosphate across the pH range encountered in the gastrointestinal tract. Chromatographic separation was achieved on a Dionex ICS-2000 IC system using a Dionex AS16, IonPac (4mmx250mm) analytical column and Dionex AG16, IonPac (4mmx50mm) guard column. Column temperature was maintained at 30 degrees C. Injection volume was 10microL. The compounds were eluted isocratically at a flow rate of 1mL/min and detected by suppressed conductivity. The analytical method was validated according to USP Category I requirements. The validation characteristics
Who reads Development and Validation of an Ion Chromatography Method for the Determination of Phosphate-binding of Lanthanum Carbonate?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Raghu Samy; Patrick J. Faustino; Wallace Adams; Lawrence Yu; Mansoor A. Khan; Yongsheng Yang
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)