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Orodispersible Films and Tablets with Prednisolone Microparticles by Witold Brniak; Ewelina Maślak; Renata Jachowicz is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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a b s t r a c t 26 Orodispersible tablets (ODTs) and orodispersible films (ODFs) are solid oral dosage forms disintegrating 27 or dissolving rapidly when placed in the mouth. One of the main issues related to their preparation is an 28 efficient taste masking of a bitter drug substance. Therefore, the aim of this study was to prepare and 29 evaluate the microparticles intended to mask a bitter taste of the prednisolone and use them in further 30 preparation of two orodispersible dosage forms. Microparticles based on the Eudragit E PO or E 100 as a 31 taste-masking agent were prepared with spray-drying technique. Tablets containing microparticles, co-32 processed ODT excipient Pharmaburst, and lubricant were directly compressed with single-punch tablet 33 press. Orodispersible films were prepared by casting polymeric solutions of hydroxypropyl methyl-34 cellulose containing uniformly dispersed microparticles. Physicochemical properties of microparticles 35 were evaluated, as well as mechanical properties analysis, disintegration time measurements and 36 dissolution tests were performed for prepared dosage forms. Both formulations showed good mechanical 37 resistance while maintainin

Who reads Orodispersible Films and Tablets with Prednisolone Microparticles?

Author

Witold Brniak; Ewelina Maślak; Renata Jachowicz

Publisher

Elsevier BV

Published

2015

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)