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Potential Aetiological Factors Concerning the Development of Osteonecrosis of the Femoral Head by CH. Zalavras; Dailiana; Elisaf; Bairaktari; Vlachogiannopoulos; Katsaraki; Malizos is a Medicine article available to read on EtoBox.

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## Background The aetiology and pathogenesis of non‐traumatic osteonecrosis (ON) of the femoral head have not been fully elucidated. The present study was conducted to evaluate the possible correlation of relevant haematological and biochemical factors with the development of ON. ## Patients and methods Our investigation consisted of measurement of haematological indices and assessment of the biochemical and lipid profile of a study population of 68 patients with non‐traumatic ON of the femoral head and 36 healthy controls. The disease was considered idiopathic in 17 and secondary in 51 patients. ## Results There were no statistically significant differences in the parameters measured among the idiopathic ON, secondary ON and control groups, except for globulins α1, α2 and β, which were significantly increased in both patient groups, and apolipoprotein B (Apo B), which was increased in patients with idiopathic disease compared with the control group. Both patient groups presented increased von Willebrand factor (VWF) and lipoprotein (a) [Lp(a)] levels and decreased protein C and S concentrations, but without statistical significance. However, both patient groups exhibited a greater

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Author

CH. Zalavras; Dailiana; Elisaf; Bairaktari; Vlachogiannopoulos; Katsaraki; Malizos

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0014-2972)

Published

2000

Language

EN

Field

Medicine (Health Sciences)