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Preoperative Concurrent Radiation Therapy and Chemotherapy for Bulky Stage IB2, IIA, and IIB Carcinoma of the Uterine Cervix With Proximal Parametrial Invasion by Florence Huguet; Oana-Maria Cojocariu; Pierre Levy; Jean-Pierre Lefranc; Emile Darai; Denis Jannet; Yan Ansquer; Pierre-Eugène Lhuillier; Jean-Louis Benifla; Nathalie Seince; Emmanuel Touboul is a Medicine article available to read on EtoBox.

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## Purpose: To evaluate toxicity, local tumor control, and survival after preoperative chemoradiation for operable bulky cervical carcinoma. ## Methods and materials: Between december 1991 and july 2006, 92 patients with operable bulky stage ib2, iia, and iib cervical carcinoma without pelvic or para-aortic nodes on pretreatment imaging were treated. treatment consisted of preoperative external beam pelvic radiation therapy (ebrt) and concomitant chemotherapy (ct) during the first and fourth weeks of radiation combining 5-fluorouracil and cisplatin. the pelvic radiation dose was 40.5 gy over 4.5 weeks. ebrt was followed by low-dose rate uterovaginal brachytherapy with a total dose of 20 gy in 62 patients. after a median rest period of 44 days, all patients underwent class ii modified radical hysterectomy with bilateral pelvic lymphadenectomy. thirty patients who had not received preoperative uterovaginal brachytherapy underwent postoperative low-dose-rate vaginal brachytherapy at a dose of 20 gy. the mean follow-up was 46 months. ## Results: Pathologic residual tumor was observed in 43 patients. after multivariate analysis, additional preoperative uterovaginal brachytherapy was the

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Author

Florence Huguet; Oana-Maria Cojocariu; Pierre Levy; Jean-Pierre Lefranc; Emile Darai; Denis Jannet; Yan Ansquer; Pierre-Eugène Lhuillier; Jean-Louis Benifla; Nathalie Seince; Emmanuel Touboul

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2008

Language

EN

Field

Medicine (Health Sciences)