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The article investigates the interaction between adriamycin (ADM), an anticancer drug, and the regulatory element of HMGB1, a protein associated with various cancers. Using spectroscopic and calorimetric techniques, the study reveals that ADM forms a strong and stable complex with DNA, indicating its potential as a chemotherapeutic target in treating cancers linked to HMGB1 upregulation. The findings suggest that ADM binds to DNA in a non-cooperative manner and operates through an intercalative mode of bind

Author

Himanshu Singh

Language

EN