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Synthesis and Anti-plasmodial Activity of Isoandrographolide Acetals by Nitesh Tamang; Sai Kiran Mavileti; Mamta Yadav; Srinivas Nanduri; Dinkar Sahal; Nageswara Rao Golakoti is a Chemistry article available to read on EtoBox.
What is Synthesis and Anti-plasmodial Activity of Isoandrographolide Acetals about?
Isoandrographolide (2) and its nineteen acetals (3a-3o, 4, 5 and 6a-6b) of which fifteen are new were synthesized and characterized using 1 H-NMR, 13 C-NMR, mass spectrometry, and IR spectroscopy. The compound 3c was characterized using single-crystal X-ray diffraction as well. All the compounds were tested for their anti-plasmodial potencies (IC 50 ) against the Chloroquine sensitive Pf3D7 and chloroquine resistant PfINDO strains. Potent compounds were further tested also for their cytotoxicity (CC 50 ) against mammalian cells. Compounds 3d (IC 50 10.59 μM) and 3e (IC 50 12.83 μM) were found to be the most active with mammalian cell CC 50 > 100 μM for both the compounds.
Who reads Synthesis and Anti-plasmodial Activity of Isoandrographolide Acetals?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Nitesh Tamang; Sai Kiran Mavileti; Mamta Yadav; Srinivas Nanduri; Dinkar Sahal; Nageswara Rao Golakoti
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)