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What is Nonlinear Mixed-Effects Modeling in Pharmacokinetics about?

This study evaluated the advantages of using nonlinear mixed-effects modeling (NMEM), as implemented in NONMEM, compared to the standard two-stage method for detecting and characterizing nonlinear pharmacokinetic and pharmacodynamic processes using data from a few subjects receiving multiple doses. Simulations were conducted for 3 nonlinear situations: 2 pharmacokinetic models involving saturable elimination and 1 pharmacodynamic model. NMEM with FOCE enabled detection and characterization of the true nonli

Author

Bagoes As

Language

EN