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Risk factors of severe hepatotoxicity among HIV-1 infected individuals initiated on highly active antiretroviral therapy in the Northwest Region of Cameroon by Lem Edith Abongwa; Anthony Kebira Nyamache; Fokunang Charles; Judith Torimiro; Nshom Emmanuel; Irénée Domkam; Mbu Eyongetah; Beriyuy Jude; Fung Holgar Mua; Sama Bella; Tankou Colman Tamboh; Erna Charlene Moungang; Victorine Ngum; Paul Okemo is a Medicine article available to read on EtoBox.

What is Risk factors of severe hepatotoxicity among HIV-1 infected individuals initiated on highly active antiretroviral therapy in the Northwest Region of Cameroon about?

## Background Hepatotoxicity due to highly active antiretroviral therapy (HAART) has gained prominent attention since it can be affected by many factors. The aim of this study was to determine the prevalence of hepatotoxicity and related risk factors of severe hepatotoxicity following HAART initiation. ## Methods A total of 100 drug-naive patients aged between 18 and 61 years were recruited. They were put on Tenofovir/Lamivudine/Efavirenz [TDF/3TC/EFV] (64), Zidovudine/ Lamivudine/Efavirenz [AZT/3TC/EFV] (22), and Zidovudine/Lamivudine/Nevirapine AZT/3TC/NVP (14) and monitored for 6months and blood samples drawn.Alanine aminotransferases (ALT), aspartate aminotransferases (AST), and alkaline phosphatase (ALP) wereanalyzed by enzymatic methods and used to classify levels of hepatotoxicity. ## Results A total of 37(37%) and 49(49%) patients presented with hepatotoxicity while 15% and 28% had severe hepatotoxicity at 4 and 24 weeks respectively. Serum levels of all enzymes increased significantly (__p__ = 0.001) with increased treatment duration. Univariate analysis revealed that the risk factor of developing severe hepatotoxicity was significantly greater in patients < 30years (__p__

Who reads Risk factors of severe hepatotoxicity among HIV-1 infected individuals initiated on highly active antiretroviral therapy in the Northwest Region of Cameroon?

Author

Lem Edith Abongwa; Anthony Kebira Nyamache; Fokunang Charles; Judith Torimiro; Nshom Emmanuel; Irénée Domkam; Mbu Eyongetah; Beriyuy Jude; Fung Holgar Mua; Sama Bella; Tankou Colman Tamboh; Erna Charlene Moungang; Victorine Ngum; Paul Okemo

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)