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Idiopathic Generalized Epilepsy: Misunderstandings, Challenges, and Opportunities by Orrin Devinsky; Christopher Elder; Shobi Sivathamboo; Ingrid E. Scheffer; Matthias J. Koepp is a Medicine article available to read on EtoBox.

What is Idiopathic Generalized Epilepsy: Misunderstandings, Challenges, and Opportunities about?

The idiopathic generalized epilepsies (IGE) make up a fifth of all epilepsies, but <1% of epilepsy research. This skew reflects misperceptions: diagnosis is straightforward, pathophysiology is understood, seizures are easily controlled, epilepsy is outgrown, morbidity and mortality are low, and surgical interventions are impossible. Emerging evidence reveals that patients with IGE may go undiagnosed or misdiagnosed with focal epilepsy if EEG or semiology have asymmetric or focal features. Genetic, electrophysiologic, and neuroimaging studies provide insights into pathophysiology, including overlaps and differences from focal epilepsies. IGE can begin in adulthood and patients have chronic and drug-resistant seizures. Neuromodulatory interventions for drug-resistant IGE are emerging. Rates of psychiatric and other comorbidities, including sudden unexpected death in epilepsy, parallel those in focal epilepsy. IGE is an understudied spectrum for which our diagnostic sensitivity and specificity, scientific understanding, and therapies remain inadequate. ## History and Background Mid-to-late 19th-century neurologists distinguished patients with idiopathic epilepsy from those with sympto

Who reads Idiopathic Generalized Epilepsy: Misunderstandings, Challenges, and Opportunities?

Author

Orrin Devinsky; Christopher Elder; Shobi Sivathamboo; Ingrid E. Scheffer; Matthias J. Koepp

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2024

Language

EN

Field

Medicine (Health Sciences)