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Genomic organization, DNA sequence, and expression of chicken embryonic histone genes. by B J Sugarman; J B Dodgson; J D Engel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Genomic organization, DNA sequence, and expression of chicken embryonic histone genes. about?
We have isolated and characterized in detail 15 lambda Charon 4A recombinant bacteriophage containing histone genes from a chicken genomic library. Restriction enzyme-mapping analysis and Southern hybridization to sequenced, homologous histone probes indicate that these genes are not tandemly reiterated within the chicken genome; they usually reside in clusters even though there is no unique array of genes that appears to constitute a typical cluster. Chicken H4 and H1 genes were identified within the genomic recombinants and subsequently sequenced. Extensive regions of homology exist in the 5'- and 3'-flanking regions of the chicken H4 gene when compared to H4 genes from other organisms. In addition to the well documented histone-specific domains, two previously unreported regions of homology lie 5' to this gene: an octanucleotide and a pentanucleotide sequence lying 59 and 116 nucleotides upstream from the H4 gene CAP site, respectively. The H1 gene sequence predicts that the H1 polypeptide is 217 amino acids in length. The 5'-flanking domain of this gene contains, in addition to the transcriptional initiation site and the ATA box, two unusual sequences: one is a nonamer which re
Who reads Genomic organization, DNA sequence, and expression of chicken embryonic histone genes.?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- B J Sugarman; J B Dodgson; J D Engel
- Publisher
- Elsevier BV
- Published
- 1983
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)