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The article discusses the discovery of two HIV-1 integrase inhibitors, dolutegravir and S/GSK1265744, derived from carbamoyl pyridone analogues designed using a two-metal chelation model. These inhibitors exhibit potential for once-daily dosing and improved potency against resistant viral strains, achieved through a diastereomeric approach to control stereochemistry during synthesis. The study highlights the evolution of tricyclic carbamoyl pyridone structures and their promising antiviral profiles, current

Author

shavkar sharada devi

Language

EN