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Can I read Molecular Subtypes of Breast Cancer Predicting Clinical Benefits of Radiotherapy After Breast-conserving Surgery: a Propensity-score-matched Cohort Study on EtoBox?
Molecular Subtypes of Breast Cancer Predicting Clinical Benefits of Radiotherapy After Breast-conserving Surgery: a Propensity-score-matched Cohort Study by Shih-Kai Hung; Hsuan-Ju Yang; Moon-Sing Lee; Dai-Wei Liu; Liang-Cheng Chen; Chia-Hui Chew; Chun-Hung Lin; Cheng-Hung Lee; Szu-Chin Li; Chung-Lin Hong; Chih-Chia Yu; Ben-Hui Yu; Feng-Chun Hsu; Wen-Yen Chiou; Hon-Yi Lin is a Medicine article available to read on EtoBox.
What is Molecular Subtypes of Breast Cancer Predicting Clinical Benefits of Radiotherapy After Breast-conserving Surgery: a Propensity-score-matched Cohort Study about?
## Abstract ## Background Based on the molecular expression of cancer cells, molecular subtypes of breast cancer have been applied to classify patients for predicting clinical outcomes and prognosis. However, further evidence is needed regarding the influence of molecular subtypes on the efficacy of radiotherapy (RT) after breast-conserving surgery (BCS), particularly in a population-based context. Hence, the present study employed a propensity-score-matched cohort design to investigate the potential role of molecular subtypes in stratifying patient outcomes for post-BCS RT and to identify the specific clinical benefits that may emerge. ## Methods From 2006 to 2019, the present study included 59,502 breast cancer patients who underwent BCS from the Taiwan National Health Insurance Research Database. Propensity scores were utilized to match confounding variables between patients with and without RT within each subtype of breast cancer, namely luminal A, luminal B/HER2-negative, luminal B/HER2-positive, basal-like, and HER2-enriched ones. Several clinical outcomes were assessed, in terms of local recurrence (LR), regional recurrence (RR), distant metastasis (DM), disease-free surviva
Who reads Molecular Subtypes of Breast Cancer Predicting Clinical Benefits of Radiotherapy After Breast-conserving Surgery: a Propensity-score-matched Cohort Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shih-Kai Hung; Hsuan-Ju Yang; Moon-Sing Lee; Dai-Wei Liu; Liang-Cheng Chen; Chia-Hui Chew; Chun-Hung Lin; Cheng-Hung Lee; Szu-Chin Li; Chung-Lin Hong; Chih-Chia Yu; Ben-Hui Yu; Feng-Chun Hsu; Wen-Yen Chiou; Hon-Yi Lin
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Field
- Medicine (Health Sciences)