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Investigation of Safety for Electrochemotherapy and Irreversible Electroporation Ablation Therapies in Patients with Cardiac Pacemakers by Jarm, Tomaz; Krmac, Tadej; Magjarevic, Ratko; Kos, Bor; Cindric, Helena; Miklavcic, Damijan is a Medicine article available to read on EtoBox.
What is Investigation of Safety for Electrochemotherapy and Irreversible Electroporation Ablation Therapies in Patients with Cardiac Pacemakers about?
## Abstract ## Background The effectiveness of electrochemotherapy of tumors (ECT) and of irreversible electroporation ablation (IRE) depends on different mechanisms and delivery protocols. Both therapies exploit the phenomenon of electroporation of the cell membrane achieved by the exposure of the cells to a series of high-voltage electric pulses. Electroporation can be fine-tuned to be either reversible or irreversible, causing the cells to either survive the exposure (in ECT) or not (in IRE), respectively. For treatment of tissues located close to the heart (e.g., in the liver), the safety of electroporation-based therapies is ensured by synchronizing the electric pulses with the electrocardiogram. However, the use of ECT and IRE remains contraindicated for patients with implanted cardiac pacemakers if the treated tissues are located close to the heart or the pacemaker. In this study, two questions are addressed: can the electroporation pulses interfere with the pacemaker; and, can the metallic housing of the pacemaker modify the distribution of electric field in the tissue sufficiently to affect the effectiveness and safety of the therapy? ## Results The electroporation pulses
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- Author
- Jarm, Tomaz; Krmac, Tadej; Magjarevic, Ratko; Kos, Bor; Cindric, Helena; Miklavcic, Damijan
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC (ISSN 1475-925X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)