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Urinary screening tests for fetal Down syndrome: II. Hyperglycosylated hCG by Laurence A. Cole; Shohreh Shahabi; Utku A. Oz; Kirsi M. Rinne; Aziza Omrani; Ray O. Bahado-Singh; Maurice J. Mahoney is a Medicine article available to read on EtoBox.

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Hyperglycosylated hCG is a form of hCG with more complex oligosaccharide side chains. A specific immunoassay was developed to measure hyperglycosylated hCG. Levels were measured in urine samples from 1157 women between 11 to 22 weeks of gestation, undergoing genetic analysis because of advanced maternal age. Values were normalized to urine creatinine concentration and plotted against gestational age, median values were determined and multiples of the control median (MoM) calculated. The median MoM and log standard deviation (log SD) of the 1134 control samples was 1.0 and 0.47, and of the 23 Down syndrome cases was 7.8 and 0.48, respectively. This indicated a 7.8-fold increase in hyperglycosylated hCG levels in Down syndrome cases. In the accompanying article, a stability problem was found with -core fragment measurements in frozen urine samples. In anticipation of similar problems, nine urine samples were tested for hyperglycosylated hCG fresh and after storage in the freezer. No clear difference was found in hyperglycosylated hCG values. In addition, no trend was found in hyperglycosylated hCG MoM values or in Down syndrome detection rates in urine samples stored for one, two or

Who reads Urinary screening tests for fetal Down syndrome: II. Hyperglycosylated hCG?

Author

Laurence A. Cole; Shohreh Shahabi; Utku A. Oz; Kirsi M. Rinne; Aziza Omrani; Ray O. Bahado-Singh; Maurice J. Mahoney

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)

Published

1999

Language

EN

Field

Medicine (Health Sciences)