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Emergence of extensively drug-resistant and multidrug-resistant Shigella flexneri serotype 2a associated with sexual transmission among gay, bisexual, and other men who have sex with men, in England: a descriptive epidemiological study by Katie Thorley; Hannah Charles; David R Greig; Mateo Prochazka; Lewis C E Mason; Kate S Baker; Gauri Godbole; Katy Sinka; Claire Jenkins is a Medicine article available to read on EtoBox.
What is Emergence of extensively drug-resistant and multidrug-resistant Shigella flexneri serotype 2a associated with sexual transmission among gay, bisexual, and other men who have sex with men, in England: a descriptive epidemiological study about?
Background Shigellosis, also known as bacillary dysentery, is caused by Shigella spp that spread through fecal-oral contact and was traditionally associated with international travel in England. However, sexual transmission of Shigella flexneri and Shigella sonnei among gay, bisexual, and other men who have sex with men (MSM) is now common. In September, 2021, emergence of extensively drug-resistant (XDR) S sonnei harbouring plasmid-encoded bla CTX-M-27 raised concerns over further spread of this extended-spectrum β-lactamase-producing gene. Using national surveillance in England, we identified and characterised isolates of S flexneri harbouring bla CTX-M-27 . Methods In this epidemiological study, we identified and phylogenetically characterised S flexneri isolates harbouring bla CTX-M-27 that were referred to the Gastrointestinal Bacterial Reference Unit (GBRU) at the UK Health Security Agency. All isolates referred to the GBRU undergo whole-genome sequencing, enabling antimicrobial resistance determination using genetic markers. Cases were defined as individuals diagnosed with S flexneri harbouring bla CTX-M-27 in England, with a specimen date between Sept 1, 2015, and June 12,
Who reads Emergence of extensively drug-resistant and multidrug-resistant Shigella flexneri serotype 2a associated with sexual transmission among gay, bisexual, and other men who have sex with men, in England: a descriptive epidemiological study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Katie Thorley; Hannah Charles; David R Greig; Mateo Prochazka; Lewis C E Mason; Kate S Baker; Gauri Godbole; Katy Sinka; Claire Jenkins
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)