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Accelerated Subcutaneous Abdominal Stem Cell Adipogenesis Predicts Insulin Sensitivity in Normal-weight Women with Polycystic Ovary Syndrome by Dumesic, Daniel A.; Tulberg, Ayli; Leung, Karen L.; Fisch, Samantha C.; Grogan, Tristan R.; Abbott, David H.; Naik, Rajanigandha; Chazenbalk, Gregorio D. is a Medicine article available to read on EtoBox.

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## Objective: To examine whether subcutaneous (sc) abdominal adipose stem cell differentiation into adipocytes in vitro predicts insulin sensitivity (si) in vivo in normal-weight women with polycystic ovary syndrome (pcos) and controls. ## Design: Prospective cohort study. ## Setting: Academic medical center. ## Patient(s): Eight normal-weight women with pcos and 8 age- and body mass index-matched controls. ## Intervention(s): Women underwent circulating hormone/metabolic determinations, intravenous glucose tolerance testing, total-body dual-energy x-ray absorptiometry, and sc abdominal fat biopsy. ## Main outcome measure(s): Pparγ and cebpa gene expression and lipid content of adipocytes matured in vitro were compared between women with pcos and control women, and correlated with patient characteristics, systemic si, and adipose insulin resistance (adipose-ir). ## Result(s): Serum androgen levels, adipose-ir, and percentage of android fat were greater in women with pcos than control women. stem cell pparγ and cebpa gene expression increased maximally by day 12 without a female-type effect. in control cells, gene expression positively correlated with fasting serum insulin levels (b

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Author

Dumesic, Daniel A.; Tulberg, Ayli; Leung, Karen L.; Fisch, Samantha C.; Grogan, Tristan R.; Abbott, David H.; Naik, Rajanigandha; Chazenbalk, Gregorio D.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1556-5653)

Published

2020

Language

EN

Field

Medicine (Health Sciences)