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In vivo MR quantification of superparamagnetic iron oxide nanoparticle leakage during low‐frequency‐ultrasound‐induced blood–brain barrier opening in swine by Hao‐Li Liu; Pin‐Yuan Chen; Hung‐Wei Yang; Jia‐Shin Wu; I‐Chou Tseng; Yan‐Jung Ma; Chih‐Ying Huang; Hong‐Chieh Tsai; Shu‐Mei Chen; Yu‐Jen Lu; Chiung‐Yin Huang; Mu‐Yi Hua; Yunn‐Hwa Ma; Tzu‐Chen Yen; Kuo‐Chen Wei is a Medicine article available to read on EtoBox.
What is In vivo MR quantification of superparamagnetic iron oxide nanoparticle leakage during low‐frequency‐ultrasound‐induced blood–brain barrier opening in swine about?
## Abstract ## Purpose: To verify that low‐frequency planar ultrasound can be used to disrupt the BBB in large animals, and the usefulness of MRI to quantitatively monitor the delivery of superparamagnetic iron oxide (SPIO) nanoparticles into the disrupted regions. ## Materials and Methods: Two groups of swine subjected to craniotomy were sonicated with burst lengths of 30 or 100 ms, and one group of experiment was also performed to confirm the ability of 28‐kHz sonication to open the BBB transcranially. SPIO nanoparticles were administered to the animals after BBB disruption. Procedures were monitored by MRI; SPIO concentrations were estimated by relaxivity mapping. ## Results: Sonication for 30 ms created shallow disruptions near the probe tip; 100‐ms sonications after craniotomy can create larger and more penetrating openings, increasing SPIO leakage ∼3.6‐fold than 30‐ms sonications. However, this was accompanied by off‐target effects possibly caused by ultrasonic wave reflection. SPIO concentrations estimated from transverse relaxation rate maps correlated well with direct measurements of SPIO concentration by optical emission spectrometry. We have also shown that transcranial
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- Author
- Hao‐Li Liu; Pin‐Yuan Chen; Hung‐Wei Yang; Jia‐Shin Wu; I‐Chou Tseng; Yan‐Jung Ma; Chih‐Ying Huang; Hong‐Chieh Tsai; Shu‐Mei Chen; Yu‐Jen Lu; Chiung‐Yin Huang; Mu‐Yi Hua; Yunn‐Hwa Ma; Tzu‐Chen Yen; Kuo‐Chen Wei
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)