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Membrane lymphotoxin-α~2~β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist by Kucka, Kirstin (author);Lang, Isabell (author);Zhang, Tengyu (author);Siegmund, Daniela (author);Medler, Juliane (author);Wajant, Harald (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Membrane lymphotoxin-α~2~β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist about?
## Abstract In the early 1990s, it has been described that LTα and LTβ form LTα~2~β and LTαβ~2~ heterotrimers, which bind to TNFR1 and LTβR, respectively. Afterwards, the LTαβ~2~–LTβR system has been intensively studied while the LTα~2~β–TNFR1 interaction has been ignored to date, presumably due to the fact that at the time of identification of the LTα~2~β–TNFR1 interaction one knew already two ligands for TNFR1, namely TNF and LTα. Here, we show that LTα~2~β interacts not only with TNFR1 but also with TNFR2. We furthermore demonstrate that membrane-bound LTα~2~β (memLTα~2~β), despite its asymmetric structure, stimulates TNFR1 and TNFR2 signaling. Not surprising in view of its ability to interact with TNFR2, LTα~2~β is inhibited by Etanercept, which is approved for the treatment of rheumatoid arthritis and also inhibits TNF and LTα.
Who reads Membrane lymphotoxin-α~2~β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kucka, Kirstin (author);Lang, Isabell (author);Zhang, Tengyu (author);Siegmund, Daniela (author);Medler, Juliane (author);Wajant, Harald (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)