Can I read Pathologic Calcification of Adult Vascular Smooth Muscle Cells Differs on Their Crest or Mesodermal Embryonic Origin on EtoBox?

Pathologic Calcification of Adult Vascular Smooth Muscle Cells Differs on Their Crest or Mesodermal Embryonic Origin by Margot Leroux‐Berger; Isabelle Queguiner; Thiago T Maciel; Andrew Ho; Frédéric Relaix; Hervé Kempf is a Medicine article available to read on EtoBox.

What is Pathologic Calcification of Adult Vascular Smooth Muscle Cells Differs on Their Crest or Mesodermal Embryonic Origin about?

## Abstract Vascular calcifications can occur in the elderly and in patients suffering from various diseases. Interestingly, depending on the pathology, different regions of the arterial system can be affected. Embryonic observations have clearly indicated that vascular smooth muscle cell (VSMC) origin is notably heterogeneous. For instance, in the aorta, VSMCs colonizing the aortic arch region derive from cardiac neural crest cells, whereas those populating the descending aorta derive from the mesoderm. We examined here whether the embryonic origin of aortic VSMCs would correlate with their ability to mineralize. Under hyperphosphatemic conditions that induce vascular calcifications, we performed ex vivo aortic explant cultures as well as in vitro VSMC cultures from wild‐type mice. Our data showed that VSMC embryonic origin affects their ability to mineralize. Indeed, the aortic arch media made up of VSMCs of neural crest origin calcifies significantly earlier than the descending aorta composed of VSMCs, which are mesoderm‐derived. Similar results were obtained with cultured VSMCs harvested from both aortic regions. We also demonstrated that in a mouse model deficient in matrix Gl

Who reads Pathologic Calcification of Adult Vascular Smooth Muscle Cells Differs on Their Crest or Mesodermal Embryonic Origin?

Author

Margot Leroux‐Berger; Isabelle Queguiner; Thiago T Maciel; Andrew Ho; Frédéric Relaix; Hervé Kempf

Publisher

American Society for Bone and Mineral Research; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0884-0431)

Published

2011

Language

EN

Field

Medicine (Health Sciences)