Can I read Venetoclax in Patients with Acute Myeloid Leukemia Refractory to Hypomethylating Agents—a Multicenter Historical Prospective Study on EtoBox?

Venetoclax in Patients with Acute Myeloid Leukemia Refractory to Hypomethylating Agents—a Multicenter Historical Prospective Study by Ron Ram; Odelia Amit; Tsila Zuckerman; Ronit Gurion; Pia Raanani; Yael Bar-On; Irit Avivi; Ofir Wolach is a Medicine article available to read on EtoBox.

What is Venetoclax in Patients with Acute Myeloid Leukemia Refractory to Hypomethylating Agents—a Multicenter Historical Prospective Study about?

Patients with acute myeloid leukemia (AML) who progress after exposure to hypomethylating agents (HMA) have a dismal prognosis. We hypothesized that the addition of venetoclax, a BCL-2 inhibitor, to AML patients who previously failed HMA might overcome resistance. Adult patients (≥ 18 years) with AML were eligible if leukemia relapsed after, or was refractory to HMA. In general, in addition to venetoclax, patients continued HMA or other low-intensity therapies. Patients who previously underwent allogeneic hematopoietic cell transplantation (HCT) were also eligible. Data were analyzed in November 2018. Twenty-three patients were treated between October 2016 and October 2018 and were eligible for this study. Median age was 76 years and 6 patients had leukemia that relapsed post allogeneic HCT. None of the patients experienced tumor lysis syndrome and toxicities were as expected and manageable. Febrile neutropenia was the most common toxicity (78% of patients). Median hospitalization time was 13 days. Forty-three percent of the patients achieved CR/CRi. Overall survival (OS) was 74% at 6 months and median OS in patients who achieved remission was 10.8 months. Higher number of blasts i

Who reads Venetoclax in Patients with Acute Myeloid Leukemia Refractory to Hypomethylating Agents—a Multicenter Historical Prospective Study?

Author

Ron Ram; Odelia Amit; Tsila Zuckerman; Ronit Gurion; Pia Raanani; Yael Bar-On; Irit Avivi; Ofir Wolach

Publisher

Springer Science and Business Media LLC

Published

2019

Language

EN

Field

Medicine (Health Sciences)