Can I read Antibody Response to Influenza Infection of Mice: Different Patterns for Glycoprotein and Nucleocapsid Antigens on EtoBox?

Antibody Response to Influenza Infection of Mice: Different Patterns for Glycoprotein and Nucleocapsid Antigens by Robert Sealy; Sherri Surman; Julia L. Hurwitz; Christopher Coleclough is a Immunology and Microbiology article available to read on EtoBox.

What is Antibody Response to Influenza Infection of Mice: Different Patterns for Glycoprotein and Nucleocapsid Antigens about?

## Summary Our previous studies of C57BL/6 mice intranasally infected with influenza virus (A/PR8) revealed a spike of virus‐specific immunoglobulin A (IgA)‐secreting antibody‐forming cells (AFC) in the mediastinal lymph node (MLN) 7 days post‐infection. Here we show that these AFC are directed only against viral glycoprotein, and not nucleocapsid antigens. The early IgA spike associates with a decline in glycoprotein‐specific AFC during week 2 post‐infection. In contrast to the glycoprotein‐specific AFC, nucleocapsid‐specific, IgA‐secreting AFC develop gradually in the MLN and persist for more than 3 weeks post‐infection. As peripheral lymph node reactions wane, the nucleocapsid‐specific AFC appear as long‐sustained populations in the bone marrow. Microanatomical examination of the respiratory tract in infected mice shows foci of infection established in the lung 2 days post‐infection, from which virus spreads to infect the entire lining of the trachea by day 3. At this time, viral haemagglutinin can be seen within the MLN, probably on projections from infected dendritic cells. This feature disappears within a day, though viral antigen expression continues to spread throughout the

Who reads Antibody Response to Influenza Infection of Mice: Different Patterns for Glycoprotein and Nucleocapsid Antigens?

Author

Robert Sealy; Sherri Surman; Julia L. Hurwitz; Christopher Coleclough

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

2003

Language

EN

Field

Immunology and Microbiology (Life Sciences)