Can I read Discovery of Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 by Docking and Pharmacophore Modeling on EtoBox?
Discovery of Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 by Docking and Pharmacophore Modeling by Huaiyu Yang; Wei Dou; Jing Lou; Ying Leng; Jianhua Shen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Discovery of Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 by Docking and Pharmacophore Modeling about?
11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) is a potential target for treatment of diabetes and metabolic syndrome. Docking and pharmacophore modeling have been used to discover novel inhibitors of 11b-HSD1. Several compounds, with large structural diversity and good potency against 11b-HSD1, have been found and their potency was determined by the enzyme assay. New scaffolds of 11b-HSD1 inhibitors are also reported.
Who reads Discovery of Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 by Docking and Pharmacophore Modeling?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Huaiyu Yang; Wei Dou; Jing Lou; Ying Leng; Jianhua Shen
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)