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MicroRNA Dysregulation in Aging and Pathologies of the Skeletal Muscle by Rachel McCormick; Katarzyna Goljanek-Whysall is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is MicroRNA Dysregulation in Aging and Pathologies of the Skeletal Muscle about?

Skeletal muscle is one of the biggest organs of the body with important mechanistic and metabolic functions. Muscle homeostasis is controlled by environmental, genetic, and epigenetic factors. Indeed, MiRNAs, small noncoding RNAs robust regulators of gene expression, have and have been shown to regulate muscle homeostasis on several levels: through controlling myogenesis, muscle growth (hypertrophy) and atrophy, as well as interactions of muscle with other tissues. Given the large number of MiRNA target genes and the important role of MiRNAs in most physiological processes and various diseases, MiRNAs may have an enormous potential as therapeutic targets against numerous disorders, including pathologies of muscle. The purpose of this review is to present the current knowledge of the role of MiRNAs in skeletal muscle homeostasis and pathologies and the potential of MiRNAs as therapeutics for skeletal muscle wasting, with particular focus on the age- and disease-related loss of muscle mass and function.

Who reads MicroRNA Dysregulation in Aging and Pathologies of the Skeletal Muscle?

Author

Rachel McCormick; Katarzyna Goljanek-Whysall

Publisher

Elsevier

Published

2017

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)