Can I read CaMKII activity contributes to homeometric autoregulation of the heart: a novel mechanism for the Anrep effect on EtoBox?

CaMKII activity contributes to homeometric autoregulation of the heart: a novel mechanism for the Anrep effect by Jan‐Christian Reil; Gert‐Hinrich Reil; Árpád Kovács; Vasco Sequeira; Mark T. Waddingham; Maria Lodi; Melissa Herwig; Shahrooz Ghaderi; Michael M. Kreusser; Zoltán Papp; Niels Voigt; Dobromir Dobrev; Svenja Meyhöfer; Harald F. Langer; Lars S. Maier; Dominik Linz; Andreas Mügge; Mathias Hohl; Paul Steendijk; Nazha Hamdani is a Neuroscience article available to read on EtoBox.

What is CaMKII activity contributes to homeometric autoregulation of the heart: a novel mechanism for the Anrep effect about?

## Key points The Anrep effect represents the alteration of left ventricular (LV) contractility to acutely enhanced afterload in a few seconds, thereby preserving stroke volume (SV) at constant preload. As a result of the missing preload stretch in our model, the Anrep effect differs from the slow force response and has a different mechanism. The Anrep effect demonstrated two different phases. First, the sudden increased afterload was momentary equilibrated by the enhanced LV contractility as a result of higher power strokes of strongly‐bound myosin cross‐bridges. Second, the slightly delayed recovery of SV is perhaps dependent on Ca^2+^/calmodulin‐dependent protein kinase II activation caused by oxidation and myofilament phosphorylation (cardiac myosin‐binding protein‐C, myosin light chain 2), maximizing the recruitment of available strongly‐bound myosin cross‐bridges. Short‐lived oxidative stress might present a new facet of subcellular signalling with respect to cardiovascular regulation. Relevance for human physiology was demonstrated by echocardiography disclosing the Anrep effect in humans during handgrip exercise. ## Abstract The present study investigated whether oxidative

Who reads CaMKII activity contributes to homeometric autoregulation of the heart: a novel mechanism for the Anrep effect?

Author

Jan‐Christian Reil; Gert‐Hinrich Reil; Árpád Kovács; Vasco Sequeira; Mark T. Waddingham; Maria Lodi; Melissa Herwig; Shahrooz Ghaderi; Michael M. Kreusser; Zoltán Papp; Niels Voigt; Dobromir Dobrev; Svenja Meyhöfer; Harald F. Langer; Lars S. Maier; Dominik Linz; Andreas Mügge; Mathias Hohl; Paul Steendijk; Nazha Hamdani

Publisher

Cambridge University Press; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0022-3751)

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)