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ChemInform Abstract: Alkyl Esters of Camptothecin and 9-Nitrocamptothecin: Synthesis, in vitro Pharmacokinetics, Toxicity, and Antitumor Activity. by Z. CAO; N. HARRIS; A. KOZIELSKI; D. VARDEMAN; J. S. STEHLIN; B. GIOVANELLA is a Chemistry article available to read on EtoBox.

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Alkyl Esters of Camptothecin and 9-Nitrocamptothecin: Synthesis, in vitro Pharmacokinetics, Toxicity, and Antitumor Activity. -Eleven title esters (I) are synthesized to evaluate their biological properties in comparison with those of their parent compounds camptothecin and 9nitrocamptothecin. Especially esters (Ia) and (Id) exhibit significant antitumor activity combined with little or no toxicity in vivo. Furthermore, in vitro pharmacokinetic evaluation shows that the biological life span of their closed lactone form is significantly increased in comparison to their parent compounds.

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Author

Z. CAO; N. HARRIS; A. KOZIELSKI; D. VARDEMAN; J. S. STEHLIN; B. GIOVANELLA

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley (ISSN 0931-7597)

Published

1998

Language

EN

Field

Chemistry (Physical Sciences)